Yvan Cam

Yvan Cam


Agreenskills
session, year:
2013 2nd

Status:
Former fellow

Receiving laboratory:
Physiology and Genetics of Lower eukaryotes, Goethe University,

Country of origin:

France

Country of destination:

Germany

Last available contact

Email(s):
yvancam31@gmail.com

Website(s):
http://www.bio.uni-frankfurt.de/...

CV:
Download Curriculum Vitae

Mobility project

Development of a new synthetic assimilation pathway for the assimilation of pentose sugars

Evolution has selected microorganisms optimized for using carbon sources like hexoses and pentoses to increase their biomass. Metabolic engineering focuses on redirect the carbon flux from the biomass production to the production of molecules with high added-value. The mobility project consists in designing a synthetic metabolic pathway to assimilate xylose in Saccharomyces cerevisiae to allow it to produce two carbons compounds of industrial interest: glycolic acid and ethylene glycol instead of more biomass. Then, S. cerevisiae will be designed to co-assimilate both xylose and glucose.

Biography & research interests

I hold an Msc in microbiology and a PhD in interaction between plants and microorganisms. During this period I worked on the role of nitric oxide in the nitrogen fixing symbiosis between Sinorhizobium meliloti and Medicago truncatula in Claude Bruand’s group in the laboratory of plant-microorganism interaction, granted by a “contrat jeune scientifique” from INRA. I have epublished during my PhD four articles in peer-reviewed journals and one patent. My first post-doc was financed by my contrat jeune scientific grant and AgreenSkills programme. I was working on synthetic biology in microorganism metabolism in JeanMarie François’s group in the laboratory of system biology engineering and processes. Then I earned a grant for project called Pentosys through the Toulouse white biotechnology. This project consisted in building synthetic metabolic pathways for the assimilation of pentoses in microorganisms for the production of high value products. Afterwards, I performed this work on Escherichia coli. I spent 9 months in Eckhard Boles’s lab in Frankfurt, Germany, to pursue my post-doc project. I wish to pursue my career in the field of synthetic biology.

Selected publications

Bozdag, ZK; Kurkcuoglu, A; Ustdal, A; Cam, Y; Oguz, O, 2017. Upper and Lower Lip Soft Tissue Thicknesses Differ in Relation to Age and Sex. International Journal of Morphology, 35 (3), 852-858.

Alkim, C; Trichez, D; Cam, Y; Spina, L; Francois, JM; Walther, T, 2016. The synthetic xylulose-1 phosphate pathway increases production of glycolic acid from xylose-rich sugar mixtures. Biotechnology for Biofuels,  9( ), 201. Doi: 10.1186/s13068-016-0610-2.

Alkim, C; Cam, Y; Trichez, D; Spina, L; Francois, JM; Walther, T, 2016. Simultaneous production of glycolic acid via the glyoxylate shunt and the synthetic (D)-xylulose-1 phosphate pathway increases product yield. New Biotechnology, 33( ). Doi: 10.1016/j.nbt.2016.06.770.

Cam, Y; Alkim, C; Trichez, D; Trebosc, V; Vax, A; Bartolo, F; Besse, P; Francois, JM; Walther, T, 2016. Engineering of a Synthetic Metabolic Pathway for the Assimilation of (D)Xylose into Value-Added Chemicals. Acs Synthetic Biology, 5( 7), 607-618. Doi: 10.1021/acssynbio.5b00103.

Alkim, C; Cam, Y; Trichez, D; Auriol, C; Spina, L; Vax, A; Bartolo, F; Besse, P; Francois, JM; Walther, T, 2015. Optimization of ethylene glycol production from (D)-xylose via a synthetic pathway implemented in Escherichia coli. Microbial Cell Factories, 14( ), 127. Doi: 10.1186/s12934015-0312-7.

Awards & patents

Bruand C., Y. Cam, E. Meilhoc. A method for increasing legume productivity by cultivating a plant with an associated rhizobium overexpressing a flavohemoglobin protein. Ref: 359920D28984. International patent.

Keywords

“Microbiology” “ synthetic biology” “ metabolism” “ pentoses assimilation”