FranceCountry of destination:
United States of America
The research project that I develop at INRA aims to explore the molecular genetic mechanisms of adaptability of farm animals. My sabbatical at Memphis offers the possibility to study the same scientific issues in a model species, the mouse, with an advanced knowledge of its genome and the availability of numerous genetic tools, including the genetic reference populations such as the BXD panel of recombinant inbred strains. Our goal is to develop a comprehensive animal model to answer the fundamental question: what are the molecular bases for individual differences in adaptation to stress, and what are the underlying biobehavioral mechanisms?
I am a permanent scientist at the French National Institute for Agricultural Research, with a wide experience in molecular analysis of genetic variability of stress responses. After completing a Master of Science at the Moscow State University, I studied behavioral and neuroendocrine mechanisms involved in the process of adaptation during my PhD and post-doctoral fellowship at Bordeaux University and INRA. My research project, the molecular analysis of the genetic variability of stress responses is a critical topic to improve robustness and welfare of farm animals. Since my recruitment as a scientist at INRA (Laboratory for PsychoNeuroImmunology, Nutrition and Genetics, INRA Bordeaux, then Laboratory of Livestock Genetics, Physiology and Breeding, INRA Toulouse), I have studied in more detail the genetic variability of behavioural and biological responses, especially of the hypothalamic-pituitary-adrenal axis, and its functional consequences on robustness and production traits. These three components (behavior, biology, production) are studied in pigs with an integrative approach. My scientific ambition is to deliver a strategy for genetic selection of more robust animals. My unique objective is to explore the genetic architecture of stress responses in an integrated way (system genetics) and the functional consequences of genetic variability, with the aim of the practical use of this knowledge in genetic selection.
Terenina E, Sautron V, Ydier C, Bazovkina D, Sevin-Pujol A, Gress L, Lippi Y, Naylies C, Billon Y, Liaubet L, Mormede P, Villa-Vialaneix N., 2017. Time course study of the response to LPS targeting the pig immune gene networks. BMC Genomics. 18(1): 988. Doi:10.1186/s12864-017-4363-5.
Bacou E, Haurogné K, Mignot G, Allard M, De Beaurepaire L, Marchand J, Terenina E, Billon Y, Jacques J, Bach JM, Mormède P, Hervé J, Lieubeau B., 2017. Acute social stress-induced immunomodulation in pigs high and low responders to ACTH. Physiol Behav. 169(1): 1-8. Doi: 10.1016/j.physbeh.2016.11.012
Terenina E, Fabre S, Bonnet A, Monniaux D, Robert-Granié C, SanCristobal M, Sarry J, Vignoles F, Gondret F, Monget P, Tosser-Klopp G., 2017. Differentially expressed genes and gene networks involved in pig ovarian follicular atresia. Physiol Genomics. 49(2):67-80.
Larzul C, Terenina E, Foury A, Billon Y, Louveau I, Merlot E, Mormede P., 2015. The cortisol response to ACTH in pigs, heritability and influence of corticosteroid-binding globulin. Animal. 9(12):1929-1934.
Sautron V, Terenina E, Gress L, Lippi Y, Billon Y, Larzul C, Liaubet L, Villa-Vialaneix N, Mormède P., 2015. Time course of the response to ACTH in pig: biological and transcriptomic study. BMC Genomics. 16(1):961. Doi: 10.1186/s12864-015-2118-8.
First Award for the thesis from Institute for Scientific Research on Beverages (IREB);
First Award for the thesis from French Society of Alcohology (SFA)