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Major depressive disorder (depression) affects 350 million people in the world, however, efficient pharmacological treatments are lacking. Recently, there has been considerable attention on the role of nutrition, particularly the amount of Omega 3 fatty acids in the development of depression. The hosting laboratory has notably demonstrated that depression induced by Omega 3 deficient diet was associated with altered synaptic plasticity. In this project, we will use patch-clamp recordings to investigate how Omega 3 deficiency impairs synaptic plasticity. This study will help the understanding of mechanisms leading to depression and may provide new strategies to reduce its incidence.
I am a neuroscientist and I am interested in the coding of neuronal information in normal and pathological conditions. I studied Biology and Neuroscience in Poitiers and Paris (France),successively. I am expert in electrophysiology techniques, which allow recording of electrical activity of neurons in the brain. During my PhD, I deciphered one of the mechanisms of action of deep brain stimulation, a therapy used for Parkinson s disease. During my postdoctoral fellowship at the University of Otago (New Zealand), I used optogenetic stimulations combined with electrophysiological recordings in freely moving rodents to better understand the pathophysiology of Parkinson s disease. I joined NutriNeuro lab in 2014 to understand how a diet supplemented in omega-3 fatty acids can protect mice against depression when they are submitted to a chronic stress protocol. Since September 2016, I am lecturer in food biology and I am continuing research on the role of nutrition on brain function. In the future, I wish to continue in this field to better understand the role of nutrition on brain functions and how it can prevent neuropsychiatric disorders.
Bosch-Bouju C, Larrieu T, Linders L, Manzoni OJ, Laye S., 2016. Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress.Cell Reports. 2, 16(5):1237-1242.
Thomazeau A, Bosch-Bouju C, Manzoni O, Laye S., 2016. Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation. Cereb Cortex, 27(4), 2571-2579.
Delpech JC, Thomazeau A, Madore C, Bosch-Bouju C, Larrieu T, Lacabanne C, Remus-Borel J, Aubert A, Joffre C, Nadjar A, Laye S., 2015. Dietary n-3 PUFAs deficiency increases vulnerability to inflammation-induced spatial memory impairment. Neuropsychopharmacology, 40(12):2774-87.
Seeger-Armbruster S, Bosch-Bouju C, Little STC, Smither RA, Hughes SM, Hyland BI, Parr-Brownlie LC., 2015. Patterned but not tonic optogenetic stimulation in motor thalamus improves reaching in acute drug-induced parkinsonian rats. The Journal of Neuroscience, 35 (3), 1211- 1216.
Bosch-Bouju C, Smither R, Hyland BI, Parr-Brownlie LC., 2014. Reduced reach-related modulation of motor thalamus neural activity in a rat model of Parkinson s disease. The Journal of Neuroscience, 34(48), 1583615886.
First Prize for the Research Staff Speaker Awards of the Otago School of Medical Science (2013) with the oral presentation: Bosch-Bouju C, Hyland BI, Parr-Brownlie LC. Movement-related neuronal activity in the motor thalamus is strongly impaired in a Parkinson s disease rat model.
Travel Fellowships from the Neurological Foundation of New Zealand and from the IBAGS committee for attending the IBAGS XI meeting in Eilat (Israel) in March 2013
Travel Fellowship from the French Neuroscience Society for attending the 10th French Neuroscience meeting in Marseille in May 2011