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Ashkan Madadlou

STLO, Rennes

Identification of dietary modulators of cognitive function in ageing using metabolomics discovery



Annual meeting: 2018

Fields-Topics: P4 Nutrition,P5 Products and Technology

Type of talk: Fellows Speed Presentation

Identification of dietary modulators of cognitive function in ageing using metabolomics discovery

Biography

I obtained BSc (in 2003), MSc (in 2005) and PhD (in 2009) degrees in Agricultural Engineering-Food Science and Technology. After obtaining my master’s degree, I was recruited by Urmia University (Iran) as lecturer for 1 year; then, I started a doctorate. Subsequent to doctoral education, I worked as research assistant professor in Iranian Research Organization for Science and Technology (Tehran) since March 2010 till March 2013, after which I joined to the Food Science Department of the University of Tehran as assistant professor till now. Then I moved to France to work as a researcher for the French National Institute for Agricultural Research (INRA) in STLO Research Unit in Rennes as an AgreenSkills+ fellow.

Abstract

Identification of dietary modulators of cognitive function in ageing using metabolomics discovery

European population is ageing. It is estimated that the proportion of old population (individuals aged>65 years) will grow from 16% in 2010 to 29% by 2060. Malnutrition is correlated with morbidity and mortality of elderly people. Malabsorption of nutrients due to pancreatic insufficiency is amongst the reasons that cause weight loss in the elderly and several human trials have clearly established that the pancreatic exocrine secretion does decline in advanced age. This project aims at developing innovative semi-solid foods and beverages specifically dedicated to deliver pancreatic secretions and tackle elderly malnutrition. An emulsion will be fabricated to deliver both highly nutritive proteins and pancreatic enzymes in the gastrointestinal tract. Whey protein microgels (WPMs) which are sub-micron dense spheres formed through heating whey proteins can deliver remarkable amounts of nutritive proteins to geriatric persons. Accompanied by supplementing with WPMs, pancreatic enzyme replacement therapy would increase wellness of older individuals. After optimization of the manufacture process, composition and stability of the formula, the nutritional performances of the products will be assessed through in vitro dynamic gastrointestinal digestion with the DIDGI® simulator, using a model of the elderly gastrointestinal tract that will be developed during this project.

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