Annual meeting: 2015
Fields-Topics: P1 Molecular and Cellular
Type of talk: Fellows Speed Presentation
I was born in Algeria and did my undergraduate and postgraduate studies in Biochemistry at the University of Paris XI. I obtained my PhD in 2003 from University Paris XI having carried out my research project at Cochin Institute (Paris). Then, I joined the Functional Genomics Institute in Montpellier for my first postdoctoral fellow from 2004 to 2009. In August 2009, I moved to Perth (Australia) where I was employed as full-time Research Assistant Professor by the University of Western Australia to work at Harry Perkins Institute of Medical Research. From 2012 to 2014, I have been appointed as Assistant Professor in the Biochemistry department in King Saud University (Saudi Arabia). In July 2014, I returned back to France as LE STUDIUM Loire Valley Institute for Advanced Studies and Marie-Curie/ AgreenSkills fellow to work at INRA-Val de Loire (Tours, France). Since January 2017, I am appointed as Assistant Professor in College of Science, Biology Department at United Arab Emirates University in Al Ain (UAE). My scientific career has two major focus: the biology of cell surface receptors and technology development based on BRET and FRET approaches applied to study different aspects of receptor function. During my career, I have published more than 50 publications with an average impact factor of 6 and having received in total more than 2500 citations.
My project aims to develop new generation of biologicals targeting GPCRs. These biologicals are antibody fragments generated from camelids, called nanobodies. I am in charge of developing a battery of molecular, biochemical, and signalling assays that will be instrumental for the development of the nanobodies. Indeed, nanobodies displaying distinct activation profiles are expected: activators versus inhibitors, full versus partial activities, competitors versus allosteric binders,… Each profile could potentially lead to valuable in vivo action; therefore accurate screening and characterization will be carried out. Furthermore, the potential clinical and agronomic applications of the nanobodies will be assessed using in vivo models.
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